FluvoxamineAdverse Effect: Increased CNS depressionClinical Management: Monitor for changes in sleep patterns as well as signs of excessive CNS depression. Downward titration of Melatonin dosage may be required during concomitant administration with Fluvoxamine.
NifedipineAdverse Effect: Increased blood pressure is seen in patients who are under Nifedipine treatment Clinical Management: Monitor for rise in blood pressure and appropriate dose adjustment of Nifedipine or withdrawal of Melatonin has to be done. |